Pregnancy Loss Testing (CMA)

Patients who have experienced a miscarriage often want to know the reason for their loss. For families seeking answers, Pacific Rim Pathology’s CMA provides an improved alternative to traditional methods.

Chromosomal Microarray (CMA) testing can help patients to:

 

Indications for use of CMA:

Intrauterine fetal demise or stillbirth

Pregnancy loss or termination in the presence of fetal abnormalities

Recurrent fetal losses of unknown etiology

CMA detects a wide range of chromosome abnormalities

Advantages of Chromsomal Microarray Analysis (CMA) over Karyotyping (Conventional chromosome analysis)

5-10 day test result turnaround time allows for faster follow up care.

Types of Test Results

There are typically three types of microarray analysis test results:

Normal: A normal test result means that microarray testing did not detect any chromosomal abnormalities at the 200KB resolution level.

Abnormal: An abnormal test result means that microarray testing did detect extra or missing chromosomal information. If your test result is abnormal, your doctor will provide more specific information about the abnormality detected and whether genetic studies on you and your partner are recommended.

Variant of Uncertain Significance (VOUS ): A VOUS result means that chromosomal microarray testing identified extra or missing genetic information but that this change is not well understood or is very rare. In this situation, it is not possible to determine with certainty whether the change to the chromosomal information was the cause of the miscarriage.

 Genetic Counseling

ACOG (American Congress of Obstetricians and Gynecologists) also states that genetic testing should always be preceded and followed by genetic counseling.  Genetic counseling typically includes, but is not necessarily limited to, a description of the test methodology; the objective of the test; risks, benefits, and limitations of testing.  Post-test counseling for a positive test (a conclusive diagnosis) may include a review of the family history, and a discussion of considering testing of at-risk family members.  Genetic counseling may also include a discussion of the potential to identify findings of uncertain significance, consanguinity, and adult-onset disease (ACOG, 2013).

Pregnancy Loss Testing Physician Brochure

POC Specimen Collection and Handling Information Sheet_rev7